I-CBD isebenzisana nohlelo lomzimba lwe-endocannabinoid, olubambe iqhaza ekulawuleni izinqubo ezahlukahlukene zomzimba emzimbeni wonke, kubandakanya nobuchopho.
I-CBD isebenzisana ne-CB1 yethu ne-CB2 receptors kanye ne-Endocannabinoid System (ECS). I-ECS idlala indima ebalulekile ekulawuleni imisebenzi ehlukahlukene yomzimba, okuhlanganisa imizwa, ukulala, isifiso sokudla, kanye nokusabela komzimba ekuphathekeni kabi nasekucindezelekeni. Ngakho-ke, i-CBD isebenzisana ne-CB1 yethu, i-CB2 receptors, kanye ne-ECS iyonke.
I-THC ibophezela kuma-receptors e-CB1 ebuchosheni, okubangela imiphumela yengqondo esiyihlobanisa nensangu.
I-CBD ayibophezeli kulawa ma-receptors, ngakho-ke, ayikhiqizi imiphumela eshintsha ingqondo eyenziwa yi-THC.
- Ikhulula ingcindezi futhi ikhuthaze umuzwa wokuzola
- Ithoba ukungakhululeki nokushuba
- Isekela ukugxila futhi ikhuphule ukuqapha
- Ikhuthaza ukululama
- Ithuthukisa ukulala nokuphumula
I-CBD itholwe ukuthi isebenzisana ne-serotonin, i-dopamine & ne-glutamate neurotransmitter systems.
- ISeratonin iyisidlulisi "sokuzizwa kahle" -> I-CBD inganciphisa ukucindezeleka futhi ithuthukise isimo sengqondo.
- I-Dopamine iyisidlulisi somvuzo & nesisusa -> I-CBD ingakhuphula ugqozi nokuziphatha kokufuna umvuzo.
- I-Glutamate iyi-neurotransmitter yokufunda nenkumbulo -> I-CBD ingakhuthaza ukugxila nokuxhumana.
- Ukozela noma ukukhathala
- Umlomo omile
- Unciphise iphango
- Uhudo
Engosini yanamuhla yebhulogi, sizoqala uhambo olujabulisayo ngokusebenzisa ukusonteka nokuguquka kobuchopho bomuntu njengoba sihlola ukuthi i-CBD isebenzisana kanjani nodaba lwethu olumpunga. Kusukela ohlelweni olungaqondakali lwe-endocannabinoid kuya kuma-neurotransmitters ajabulisayo adlalayo, sizodalula izimfihlo ze-CBD nokuthi zingenza kanjani izimpilo zethu zibe ngcono kancane. Ngakho-ke, bopha futhi ulungele uhambo olunika ugesi emhlabeni omangalisayo we-CBD nobuchopho!
I-CBD vs iTHC: Imithelela Yesethulo Engqondweni
I-CBD, emfushane ye-cannabidiol, iyinhlanganisela yemvelo, engeyona eye-psychoactive etholakala ezitshalweni ze-cannabis. Kunjalo, iphuma emndenini owodwa nensangu, kodwa bambelelani izigqoko bakwethu! I-CBD ayifani ne-THC, isakhi esidumile se-psychoactive esitholakala ku-cannabis esinikeza abasebenzisi umuzwa "ophezulu".
Umehluko omkhulu phakathi kwe-CBD ne-THC usemithelela yazo ebuchosheni. Ngenkathi I-THC ibophezela kuma-receptors e-CB1 ebuchosheni, okubangela imiphumela ye-psychoactive esiyihlobanisa nensangu, i-CBD ithatha indlela ehlukile. I-CBD ayibophezeli kulawa ma-receptors futhi, ngakho-ke, ayikhiqizi imiphumela eshintsha ingqondo eyenziwa yiTHC.
I-CBD kanye nohlelo lwe-Endocannabinoid
- I-ECS ilawula imisebenzi yomzimba efana nemizwa, ukulala, ukuthanda ukudla, kanye nokusabela ekuphatheni kabi nokushuba.
- I-ECS inama-receptors e-CB1 ebuchosheni nasesimisweni sezinzwa esimaphakathi, kanye nama-receptors e-CB2 amasosha omzimba kanye nezicubu ezizungezile.
- I-CBD isebenzisana ne-ECS, ikhuthaza ukuphumula nokukhululeka kwengcindezi ngaphandle kwemiphumela ye-psychoactive.
Ubuchopho buyingxenye ye-CB1 & CB2 receptors. Ilawula umcabango, inkumbulo, imizwa, ukuthinta, amakhono emoto, ukubona, ukuphefumula nokuningi.
1 of 19Izinso ziyingxenye ye-CB1 receptor futhi zingasefa cishe uhhafu wenkomishi yegazi njalo ngomzuzu, uma unempilo.
2 of 19I-Adrenal Gland iyingxenye ye-CB1 receptor futhi itholakala phezulu kwenso ngayinye.
3 of 19I-Adrenal Gland iyingxenye ye-CB1 receptor. Iqala emlonyeni futhi iphelele emhumeni.
4 of 19Amathambo ayingxenye ye-CB2 receptor. I-skelaton yomuntu omdala yakhiwe ngamathambo angama-206!
5 of 19Uhlelo lwe-cariovascular luyingxenye ye-CB2 receptor futhi luqukethe inhliziyo, imithambo yegazi, negazi.
6 of 19Ipheshana le-GI liyingxenye ye-CB2 receptor. I-GI Tract "ipheshana" ukudla noketshezi okudlula lapho kugwinywa futhi kumuncwa.
7 of 19Amasosha omzimba ayingxenye ye-CB2 receptor futhi iyinethiwekhi eyinkimbinkimbi yezitho, amaseli namaprotheni avikela umzimba ekuthelelekeni.
8 of 19Amaseli esibindi ayingxenye ye-CB1 & CB2 receptors. Baphula amafutha futhi bakhiqize amandla.
9 of 19Uhlelo lwezinzwa luyingxenye ye-CB2 receptor. Isebenzisa izindlela zikagesi nezamakhemikhali ukusiza zonke izingxenye zomzimba ukuthi zixhumane.
10 of 19Amanyikwe ayingxenye ye-CB2 receptor futhi adala ama-enzyme ukuze aphule ushukela, amafutha kanye nesitashi.
11 of 19Ama-Peripheral Tissues ayingxenye ye-CB2 receptor. Kumane kuyinoma yisiphi isicubu esingeyona into ebaluleke kakhulu ekusebenzeni kwezicubu ezithile zesakhiwo (isikhumba, amathumbu, amaphaphu).
12 of 19I-Spleen iyingxenye ye-CB2 receptor. Nakuba ungaphila ngaphandle kwawo, i-spleen ilawula izinga lamangqamuzana amhlophe egazi.
13 of 19Amangqamuzana Amafutha ayingxenye yesamukeli se-CB1 futhi akhethekile ukuze agcine amandla nomuzwa futhi aphendule izinguquko kubhalansi yamandla esistimu.
14 of 19Amaphaphu ayingxenye yesamukeli se-CB1 futhi indima eyinhloko inqubo yokushintshana kwegesi ebizwa ngokuthi ukuphefumula (noma ukuphefumula).
15 of 19Amaseli Emisipha ayingxenye ye-CB1 receptor futhi angamaseli akha izicubu zemisipha.
16 of 19I-Pituitary Gland iyingxenye yesamukeli se-CB1. Itholakala ngaphansi kobuchopho umsebenzi wayo oyinhloko ukugcina i-homeostasis ngaphakathi komzimba.
17 of 19I-Spinal Cord iyingxenye ye-CB1 receptor futhi igijima ukusuka phezulu kwethambo lentamo eliphakeme ukuya phezulu kwethambo eliphansi kunawo wonke ngemuva.
18 of 19I-Thyroid Gland iyingxenye ye-CB1 receptor. Itholakala ngaphambili kwentamo yakho, ilawula imisebenzi eminingi ebalulekile yomzimba wakho ngokukhiqiza nokukhipha amahomoni athile.
19 of 19Hlola i-ECS & CBD: Chofoza noma yiliphi iphuzu kumdwebo ukuze uthole imininingwane
Imiphumela ye-CBD ku-Neurotransmitter Systems
Ama-Neurotransmitters ayizithunywa zamakhemikhali ezidlala indima ebalulekile ekudluliseni amasignali phakathi kwamangqamuzana ezinzwa, ezithonya isimo sethu sengqondo, inkumbulo, kanye nokusebenza kobuchopho kukonke.
I-CBD itholwe isebenzisana nezinhlelo eziningana ze-neurotransmitter, okuhlanganisa i-serotonin, i-dopamine, ne-glutamate.
serotonin ngokuvamile ibizwa ngokuthi “i-neurotransmitter yokuzizwa kahle futhi kuhlotshaniswa nokulawulwa kwemizwelo kanye nokuphila kahle kwemizwelo. I-CBD kungenzeka Usizo thuthukisa ukubonakaliswa kwe-serotonin ngokuthonya ama-receptors ayo, okungenzeka abe nomthelela ukunciphisa ukucindezeleka kanye nesimo sengqondo esithuthukisiwe (5).
I-Dopamine, enye i-neurotransmitter eyinhloko, ihilelekile imivuzo kanye nezindlela zokukhuthaza ebuchosheni. Nakuba imiphumela ye-CBD ku-dopamine ingakaqondwa ngokugcwele, ucwaningo lubonisa ukuthi ingasiza ekuguquleni amazinga e-dopamine, okungenzeka okuthonya ugqozi nokuziphatha kokufuna umvuzo.
I-Glutamate iyi-neurotransmitter ethokozisayo eyinhloko ebuchosheni futhi idlala indima ebalulekile kuyo ukufunda kanye nenkumbulo. I-CBD ikhonjiswe ukuthi ilawula ukukhululwa kwe-glutamate, okungasiza gcina ukuxhumana kwe-neural okuphelele futhi ukuthuthukisa ukusebenza kahle kobuchopho (5).
Ngaphezu kwemiphumela yayo kuma-neurotransmitters, i-CBD ingase futhi ibambe iqhaza ekuguquleni i-synaptic plasticity, ikhono lobuchopho lokuzivumelanisa nokuhlela kabusha ukuxhumana kwe-neural. Le nqubo ibalulekile ekufundeni, ekukhumbuleni, nasekusebenzeni kwengqondo jikelele. Ngokuthonya ipulasitiki ye-synaptic, i-CBD ingaba nomthelela ekuthuthukiseni ukusebenza kwengqondo kanye nempilo yobuchopho (1)
Imithelela emi-5 ye-CBD ebuchosheni | Imiphumela Engaba Khona Yokwelapha
1. Ukukhathazeka Nokucindezeleka?
I-CBD ibonise isithembiso ekwehliseni ingcindezi nokukhuthaza ukuphumula. Ucwaningo olushicilelwe ku-Journal of Psychopharmacology lucwaninge ukuthi i-CBD ingasiza yini ukunciphisa ingcindezi kubantu abanokukhathazeka komphakathi. (2). Ngenkathi izindlela eziqondile zisacutshungulwa, umthelela we-CBD ekuboniseni i-serotonin ungadlala indima ebalulekile kule miphumela edambisa ingcindezi.
2. Ukuphathwa Kwezinhlungu?
I-CBD ifundelwe amandla ayo ekulawuleni ukungakhululeki kanye nokungezwani. Ukubuyekezwa kwe-Frontiers in Pharmacology kucwaningwe ukuthi i-CBD ingasebenza yini ekwehliseni ukungakhululeki kanye nokwenza ngcono ikhwalithi yokulala kubantu abanezimo ezingapheli (7). Imiphumela ye-CBD yokudambisa ukungezwani ingase ibangelwe ukusebenzisana kwayo nohlelo lwe-endocannabinoid, oludlala indima ekuboneni ukungakhululeki.
3. I-Neuroprotective Effects?
Ucwaningo ephephabhukwini iFrontiers in Neuroscience lwafunda ukuthi i-CBD ingasiza yini ukuvikela amangqamuzana obuchopho emonakalweni futhi isekele impilo yobuchopho (3). Le miphumela ye-neuroprotective ingase ixhunywe nekhono le-CBD lokushintsha ama-neurotransmitters kanye ne-synaptic plasticity.
4. Izakhiwo Ezinqanda Ukuvuvukala?
I-CBD ibonise izakhiwo ezipholisa ukungezwani ezingazuzisa abantu ababhekene nokukhathazeka okuhlobene nokungezwani. Ocwaningweni lwe-European Journal of Pain, i-CBD yacwaningwa kabusha uma ingasiza ekudambiseni ukungezwani kumamodeli ezilwane (4). Lo mphumela ungaba ngenxa yekhono le-CBD lokuthonya uhlelo lwe-endocannabinoid, olubandakanyeka ekuphenduleni komzimba ekucindezelekeni.
5. Ukuthuthukisa Ukulala
I-CBD ibonise izakhiwo ezipholisa ukungezwani ezingazuzisa abantu ababhekene nokukhathazeka okuhlobene nokungezwani. Ocwaningweni lwe-European Journal of Pain, i-CBD yacwaningwa kabusha uma ingasiza ekudambiseni ukungezwani kumamodeli ezilwane (6). Lo mphumela ungaba ngenxa yekhono le-CBD lokuthonya uhlelo lwe-endocannabinoid, olubandakanyeka ekuphenduleni komzimba ekucindezelekeni.
Ifomula efakiwe
Ukusekelwa kwengqondo
Buyisela ibhalansi, gxila, futhi wengeze i-CBG ohlelweni lwakho lwezempilo ngomugqa wethu Wokusekela Ngomqondo.
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I-CBD Side Effects & Ukucatshangelwa
Kubalulekile ukubhekana nemiphumela engemihle engaba khona kanye nokukhathazeka ngokuphepha. Nakuba i-CBD ngokuvamile ibhekwa njengephephile futhi ibekezelelwa kahle, abanye abantu bangase babe nemiphumela engemihle, efana nale:
- Ukozela noma ukukhathala
- Umlomo omile
- Unciphise iphango
- Uhudo
Kubalulekile ukuqaphela ukuthi izimpendulo ngazinye ku-CBD zingahluka, futhi lokho okungaba umthamo ophelele womuntu oyedwa kungabangela imiphumela engemihle komunye. Njalo qala ngomthamo ophansi futhi kancane kancane uyandise ukuze uthole izinga lakho elilungile.
Esinye isici esibalulekile okufanele sicatshangelwe ukusebenzisana kwezidakamizwa. I-CBD ingasebenzisana nemithi ethile, okuhlanganisa okokwehlisa igazi, ama-antidepressants, neminye imithi yokuquleka. Ngaphambi kokuqala i-CBD, qiniseka ukuthi uthintana nochwepheshe bezokunakekelwa kwempilo, ikakhulukazi uma uthatha noma yimiphi imithi kadokotela noma unesimo sezempilo esivele sikhona.
Sengiphetha, nakuba imiphumela yokwelapha engaba khona ye-CBD ngokungangabazeki ijabulisa, kubalulekile ukubhekana nokusetshenziswa kwayo ngokuqapha futhi ngaso sonke isikhathi ufune isiqondiso sochwepheshe ukuze uqinisekise ulwazi oluphephe kakhulu futhi olusebenza kahle kakhulu.
I-CBD kanye Nobuchopho | Imiphumela ye-CBD ebuchosheni
Futhi lapho usunakho, izihambi zobuchopho! Sike sazulazula emhlabeni oyinkimbinkimbi we-CBD kanye nokusebenzisana kwawo okuthakazelisayo nobuchopho. Kusukela ohlelweni lwe-endocannabinoid oluyindida kuya kuma-neurotransmitters anamandla, sithole ukuthi i-CBD ingasiza kanjani ukusekela impilo yobuchopho futhi inikeze izinzuzo ezingaba khona zokwelapha ezindaweni ezinjengokukhululeka kwengcindezi, ukuphatha ukungakhululeki, ukudambisa ukungezwani, kanye nokuthuthukiswa kokulala.
Yize ucwaningo luqhubeka nokuvula amandla aphelele e-CBD, kubalulekile ukuthi ubhekane nokusetshenziswa kwayo ngokuzibophezela futhi uxhumane nochwepheshe bezempilo ngaphambi kokukufaka ohlelweni lwakho lwansuku zonke. Le nhlanganisela yomlingo ingase ibe nokuningi esingakunikeza, kodwa kubalulekile ukuqinisekisa ukuthi siyisebenzisa ngokuphepha nangempumelelo ukuze sivune izinzuzo eziphezulu.
Ngakho-ke, njengoba sicela ukubingelela ohambweni lwethu olujabulisayo emhlabeni we-CBD nengqondo, masigcine izingqondo zethu zivulekile, siqhubeke nokuhlola, futhi sihlale sibeka kuqala impilo nempilo yethu. Kuze kube yi-adventure yethu elandelayo, hlalani nelukuluku futhi unakekele, abathanda ingqondo!
Imihlahlandlela eminingi ye-CBD | I-CBD & Inkumbulo
Ukuhlola Isixhumanisi Phakathi Kwe-CBD Nenkumbulo: Odinga Ukukwazi | 5 Imithelela Ebalulekile Kumsebenzi Wokuqonda
Iyasebenza
1.Batalla, Albert, et al. "Umthelela weCannabidiol Kumsebenzi Wobuchopho Bomuntu: Ukubuyekezwa Okuhlelekile." I-Frontiers in Pharmacology, 21 Jan. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7858248/.
2. Bergamaschi, Mateus M., et al. "I-Cannabidiol inciphisa ukukhathazeka okubangelwa ukukhuluma esidlangalaleni ezigulini ezi-naïve social phobia." I-PubMed, 2011, https://pubmed.ncbi.nlm.nih.gov/21307846/. Ifinyelelwe ngomhla ka-21 Ephreli 2023.
3. Campos, Alline C., et al. "Izindlela zePlastiki kanye Neuroprotective Ezihilelekile Emiphumeleni Yokwelapha ye-Cannabidiol Ezinkingeni Zengqondo." NCBI, 23 May 2017, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441138/. Ifinyelelwe ngomhla ka-21 Ephreli 2023.
4. UCosta, uBarbara, nabanye. "I-cannabidiol engeyona i-psychoactive cannabis iyinhlangano yokwelapha esebenza ngomlomo ebuhlungu obungapheli bokuvuvukala kanye ne-neuropathic." I-PubMed, 2007, https://pubmed.ncbi.nlm.nih.gov/17157290/. Ifinyelelwe ngomhla ka-21 Ephreli 2023.
5. UDe Gregorio, uDanilo, et al. "I-Cannabidiol Modulates Serotonergic Transmission futhi Ihlehlisa Kokubili I-Allodynia Nokuziphatha Okufana Nokukhathazeka Kumodeli Yobuhlungu Be-Neuropathic." Ubuhlungu, Jan. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597/. 6. Shannon, Scott, et al. "I-Cannabidiol Ekukhathazekeni Nokulala: Uchungechunge Olukhulu Lwamacala." I-PubMed, 2019, https://pubmed.ncbi.nlm.nih.gov/30624194/. Ifinyelelwe ngomhla ka-21 Ephreli 2023.
7. UVukkovic, Sonja, et al. "Ama-Cannabinoids Nobuhlungu: Imibono Emisha Evela Kuma-Old Molecules." I-PubMed, 13 Novemba 2018, https://pubmed.ncbi.nlm.nih.gov/30542280/. Ifinyelelwe ngomhla ka-21 Ephreli 2023.
