I-CBT, i-cannabicitran, yaqala ukuhlukaniswa ngasekupheleni kweminyaka yama-60s, ekuqaleni kweminyaka yama-70s futhi ivame kakhulu ku-hemp kunensangu. I-CBT ingenye yama-cannabinoids angaqondakali futhi ivela emazingeni aphansi kakhulu.
- Ivimbela ikristalu
- Okunamandla okudambisa imiphumela ye-THC
- Izici zokudambisa ukushuba nobuhlungu
- Eminye imiphumela efana ne-CBD ne-CBG
Kuleli qophelo ocwaningweni nge-CBT, akusizi ukuqhathanisa i-CBT ne-CBD. Kodwa-ke, nakhu ukuhlukaniswa okufushane kokufana nokwehluka kwe-CBT ne-CBD:
- Zombili azikho i-pyschoactive
- Zombili zingase zenze buthaka imiphumela ye-psychoactive ye-THC
- I-CBD cannabinoid icwebezela
- I-CBT ingavimbela uwoyela we-vape we-CBD ukuthi ucwebezele
Naphezu kocwaningo olulinganiselwe ku-CBT, lubonise amandla athembisayo ezifundweni ezimbalwa. Ezinye izinzuzo ezingaba khona ze-CBT yilezi:
- Okunamandla okwehlisa i-THC ohlelweni nokunciphisa imiphumela edakayo
- Amandla okunikeza impilo yamehlo
- Okungenzeka ukudambisa ukungezwani
- Amandla okuthuthukisa ibhalansi ngomzimba
Cha, i-CBT iwuhlobo lwe-cannabinoid olungadaki futhi uhlobo olulodwa, i-CBT-C, luye lwaboniswa ukuze lunciphise imiphumela emibi ye-THC.
I-CBT ibonise amandla ayo ekusizeni abantu ukuba bayeke ukubhema noma banciphise ukubhema ngokubhekana nokuziphatha okuluthayo kanye nezindlela zokucabanga ezihlobene nokubhema. Ukwengeza, ukusebenza kahle kwe-CBT kudlulela ekuvimbeleni ukucwebezela kwama-vapes e-CBD, okuyenza ibe indlela ebalulekile yokuqinisekisa umuzwa ogculisayo wokuphefumula nge-CBD.
Abacwaningi be-Hemp kancane kancane bembula amandla ayingqayizivele wengane ngayinye ama-cannabinoids. Enye yezinto ezingaqondakali kakhulu yi-CBT (i-cannabicitran). Yize ingabonisi ngaso sonke isikhathi ku-cannabis noma ivela emazingeni aphansi kakhulu, intuthuko entsha kusayensi ye-cannabis ivumela abacwaningi ukuthi bahlole izakhiwo zayo kanye nokusetshenziswa okungase kube khona. Okwamanje, kunocwaningo olulinganiselwe ngezinzuzo noma injongo ye-CBT. Kodwa-ke, njengoba imboni ye-cannabis iqhubeka nokukhula futhi ithuthuka, kubalulekile ukugcina umkhondo wezinto ezintsha ezitholakele njenge-CBT, ezingase zinikeze amathuba amasha okuthola impilo kahle kanye nemikhiqizo yabathengi.
I-Cannabis, eyaziwa ngokuthi "isitshalo sama-molecule ayinkulungwane neyodwa", inomlando ocebile wokuhlinzeka ngamathuba amasha okutholwa. Ngamathuba amasha kusayensi ye-cannabis, kungenzeka ukuthi kuhlanganiswe ngisho nama-cannabinoids ayivelakancane emikhiqizweni yezokwelapha neyabathengi. Kulo mhlahlandlela, uzofunda mayelana nezakhiwo kanye nokusetshenziswa okungenzeka kwe-CBT. Njengoba ucwaningo kule ndawo luqhubeka nokuvela, kuyajabulisa ukucabanga ukuthi yini okusha okutholakele ikusasa elingaphathela i-CBT kanye nemboni yensangu iyonke.
Iyini i-CBT Cannabinoid?
Ngaphambi kokuthi singene kokuthi kungani I-CBT kubalulekile, nansi ingcosana yomlando. I-CBT yaqala ukuhlukaniswa ngasekupheleni kweminyaka yama-60s, ekuqaleni kweminyaka yama-70s futhi ivame kakhulu ku-hemp kunensangu. Ngokusho kwe-athikili ku Insangu insangu, ososayensi bahlonze izinhlobo eziyisishiyagalolunye ezihluke kancane ze-CBT, okukholakala ukuthi zakhiwe ngazo CBDA. I-CBT ngayinye kwayisishiyagalolunye inezinhlaka zamangqamuzana ezihluke kancane.
Ngeshwa, ucwaningo olulinganiselwe lwe-CBT hemp lukhona. Okokuqala, akuvamile kakhulu, ngakho-ke ngisho nochwepheshe be-cannabis abanolwazi abazi lutho nge-cannabinoid enganakiwe. Okwesibili, isayensi ye-cannabis iyaqhubeka nokusalela emuva ekusetshenzisweni kwezentengiselwano kuze kube semthethweni wenhlangano. Indawo empunga iphumela emigomeni yokulawula yokufunda i-cannabis futhi idala ukwesaba kwezinkinga zomthetho phakathi kwabacwaningi. Kunezifundo ezimbalwa kuphela ezitholakalayo ezinikeza ukuqonda okungaphezulu ku-CBT.
Kungani usebenzisa i-CBT? | Izinzuzo ze-CBT Cannabinoid
Kuncane okwaziwayo mayelana nezinzuzo ezingaba khona ze-CBT kuleli qophelo, ikakhulukazi ngenxa yokuthi kube nezifundo ezimbalwa ezenziwe ngayo. Kodwa, siqala ukwembula ulwazi oluthile oluthakazelisayo.
Naphezu kocwaningo olulinganiselwe lwe-CBT, lubonise amandla athembisayo ezifundweni ezimbalwa. Ucwaningo lokuqala, olwenziwa ngo-2007, lwathola ukuthi i-CBT inezakhiwo ezingase ziyivumele ukuthi ilulaze iTHC ohlelweni futhi inciphise umuzwa "ophezulu" (UBrogan et al.).
Olunye ucwaningo, olwenziwe ngo-2011, lwathola ukuthi bakwazile ukuhlukanisa into efana nekhemikhali ne-CBT esitshalweni se-rhododendron. Lesi sitshalo sinomlando omude wokusetshenziswa kwezokwelapha zaseShayina, okubeka isiteji sokucwaninga okwengeziwe ngezinzuzo ezingaba khona ze-CBT (Iwata and Kitanaka). Okutholwe kulolu cwaningo kugqamisa ukubaluleka kokuhlola nokusebenzisa izinto ezingaziwa kancane etholakala esitshalweni sensangu.
Uma unentshisekelo yokuthi i-rhododendron ivame ukutuselwa ini, nakhu I-White Rabbit Institute of Healing uthi ukusetshenziswa okungahle kube khona.
Ucwaningo olwenziwa ngo-1983 lwacwaninga ukuthi i-CBT ingakwazi yini ukunciphisa ukucindezeleka kwamehlo (Elsohly et al.). Yize ucwaningo olwengeziwe ludingeka, i-CBT kungenzeka ibe nomthelela emnikelweni wokwelapha omkhulu kakhulu we-hemp, ngenxa yento ebizwa ngokuthi āumphumela wokuhlanganaā okulapho i-cannabinoid ngayinye ingeza okuthile okuhlukile esitshalweni futhi ithuthukise imiphumela yazo zonke ezinye.
Abanye abantu baze bafune izinhlobo zezimbali ze-CBD ezine-CBT ngenxa yalesi sizathu, futhi kukhona ukuhleba kokuthi ukuba khona kwe-CBT kungase kuthuthukise imiphumela ye-CBD ekucindezelekeni okupholisayo ikakhulukazi. Futhi, njengoba kuvela, i-CBT-C (efana namakhemikhali njenge-CBT) isetshenziswe emithini yendabuko yamaShayina izinkulungwane zeminyaka ukuthuthukisa impilo kahle.
Inkampani ebizwa nge-GVB Biopharma inethemba lokuxhasa ucwaningo olwengeziwe ku-CBT, ngoba njengoba besho, "Kungase kuphikiswane ngokuthi odokotela be-TCM sekungamakhulu eminyaka besebenzisa i-CBT, beboleka ukuba semthethweni ocwaningweni lwesimanje lwe-CBT."
Futhi ngonyaka odlule nje, ucwaningo olusha lwabheka ukuthi i-cannabitriol, efana namakhemikhali afana ne-CBT, ingasetshenziswa njenge-estrogen receptor agonist engaba khona, okusho ukuthi ingase ikhuthaze ukulinganisela ngomzimba (Kikiowo et al.). Kodwa, ngaphambi kokuba sijabule kakhulu, ucwaningo olwengeziwe luyadingeka ukuze kuqinisekiswe lokhu okutholakele. Ngakho-ke, hlala ubukele njengoba sembula izinzuzo ezingaba khona zale cannabinoid engacacile.
At Extract Labs, siyaliqonda inani le-CBT futhi siyifake emikhiqizweni yethu ye-vape ye-CBD. Konke Extract Labs Ama-vapes e-CBD enziwe kusuka izithako ze-cannabis futhi ungacwebezeli, uwenze ahluke kwamanye amathangi emvelo emakethe. Lokhu kuzuzwe ngokuhlolwa kwangaphakathi kwethimba lethu ngelebhu, elisebenze ukuhlukanisa nokusebenzisa i-CBT ngempumelelo.
I-CBT kungenzeka ibe neqhaza emnikelweni wokwelapha omkhulu kakhulu we-hemp, ngenxa yokuthi i-cannabinoid ngayinye ingeza okuthile okuhlukile esitshalweni futhi ithuthukisa imiphumela yazo zonke ezinye.
I-CBT Cannabinoid Effects
Ngaphandle kokuvimbela ngokwemvelo ukucwebezela nokuba nemiphumela efana naleyo ye-CBD ne-CBG, ucwaningo oluncane olutholakalayo lubonisa ukuthi i-CBT ingaba neminye imiphumela.
Ocwaningweni lwango-2007 oluthi I-THCIzimfanelo eziluthayo, abacwaningi bathole ukuthi i-CBT yenza okufanayo I-CBD emandleni ayo okudambisa imiphumela ye-psychoactive I-THC, ngokusho kwesizinda somlando we-cannabis Iworkshop58.
Futhi, i-CBT ibonakala iveza imiphumela ecashile ekhumbuza i-CBD, eyaziwa ngezindawo zayo zokuphumuza ingqondo, kanye ne-CBG, eyaziwa ngamandla ayo ekukhuthazeni umuzwa wokulinganisela nokugxila. Njengoba i-CBT isalokhu iyingxenye engacacile futhi engasetshenziswa kancane ye-hemp, ubufakazi obuphelele be-anecdotal buyantuleka, okusishiya nokuqonda okungaphelele kokuthi ingabathinta kanjani abantu ngabanye.
I-CBT vs CBD
Okwamanje, akusizi ukuqhathanisa i-CBT ne-CBD. Asazi ngokwanele mayelana ne-CBT okwamanje. Kepha nakhu ukuhlukaniswa okufushane kokufana nokwehluka kwe-CBT ne-CBD.
- I-CBD futhi i-CBT ayisebenzi ngokwengqondo
- I-CBD kanye ne-CBT kokubili kungase kwenze buthaka imiphumela ye-psychoactive ye I-THC
- I-CBD i-cannabinoid icwebezela
- I-CBT ingavimbela CBD vape oil kusuka ku-crystalizing
I-CBT vs CBN
Omunye umehluko omkhulu yilokho I-CBN iwumkhiqizo wokuqhekeka we I-THC, okusho ukuthi yakheka nini I-THC sichayeke ekushiseni, ekukhanyeni, noma emoyeni. Ngakolunye uhlangothi, i-CBT iyinhlanganisela yemvelo etholakala esitshalweni se-cannabis, kodwa ikhona ezindaweni eziphansi kakhulu uma iqhathaniswa namanye ama-cannabinoids afanayo. I-THC futhi I-CBD.
Omunye umehluko yilokho I-CBN kucatshangwa ukuthi inezinto zokupholisa futhi ingase ibe usizo ukukhuthaza ukulala. Ucwaningo luye lwabonisa lokho I-CBN kungase kuthuthukise ukuphumula. I-CBT, ngakolunye uhlangothi, ingase ibe nezakhiwo ezidambisa ukucindezeleka kanye nezinhlungu, kodwa ucwaningo olwengeziwe luyadingeka ukuze uqonde ngokugcwele izinzuzo zayo zokwelapha ezingaba khona.
I-CBN waziwa nangokuthi unobudlelwano CB2 ama-receptors, atholakala kuwo wonke umzimba futhi alawule ubuhlungu, ukuvuvukala, nemisebenzi yamasosha omzimba. I-CBT, nokho, ingasebenzisana nohlelo lwe-endocannabinoid ngokubophezela ku- CB1 futhi CB2 receptors.
I-CBT vs CBC
Just like I-CBD futhi I-CBN, CBC kucatshangwa ukuthi isebenzisana nohlelo lwe-endocannabinoid ngokubophezela ku- CB1 futhi CB2 ama-receptors. Ibuye ibe nokuhambisana I-TRPV1 ama-receptors, ahilelekile ekuboneni ubuhlungu, izinga lokushisa, nokuvuvukala. I-CBT, ngakolunye uhlangothi, ingase futhi ihlanganyele nohlelo lwe-endocannabinoid ngokubophezela kuma-receptors e-CB1 kanye ne-CB2, kodwa ucwaningo olwengeziwe luyadingeka ukuze kuqondwe izindlela ezithile zokuthi isebenzisana kanjani nohlelo lwe-endocannabinoid.
I-CBT vs iTHC
CBT futhi I-THC zombili izinhlanganisela ezitholakala esitshalweni sensangu, kodwa zinemiphumela ehlukene emzimbeni nasengqondweni.
Umehluko oyinhloko ukuthi i-CBT ikhona ezindaweni eziphansi kakhulu ezitshalweni ze-cannabis uma kuqhathaniswa I-THC. Lokhu kusho ukuthi mancane amathuba okuthi atholakale enanini eliphezulu ngokwanele ukuze abe nomthelela omkhulu emzimbeni noma engqondweni. I-THC, ngakolunye uhlangothi, ingatholakala ezindaweni eziphakeme kakhulu futhi ibhekwa njengesithako esiyinhloko esisebenzayo ensanguni.
Imiphumela ye-CBT ayifundwa kahle futhi akukho okuningi okwaziwayo mayelana nemiphumela yayo ethile yengqondo. I-THC, ngakolunye uhlangothi, iyinhlanganisela eyinhloko ye-psychoactive ku-cannabis futhi yaziwa ngokukhiqiza "okuphezulu" okuhlotshaniswa nokusetshenziswa kwensangu.
Olunye ucwaningo lwathola ukuthi lucwaningiwe uma i-CBT inezinto ezingaba khona zokudambisa ukungezwani, ezingase ziyenze ibe usizo ekwelapheni ukungakhululeki nobuhlungu. Olunye ucwaningo lwabheka ukuthi i-CBT ingaba nezakhiwo zokuthulisa, ezingenza kube usizo ukukhuthaza ukulala.
I-CBT ingase ibe nomthelela ohlelweni lwe-endocannabinoid. Uhlelo lwe-endocannabinoid luwuhlelo oluyinkimbinkimbi lokubonisa amaseli oludlala indima ekulawuleni izinqubo ezihlukahlukene zomzimba emzimbeni, njengobuhlungu, imizwa, nesifiso sokudla.
I-CBT ingase ihlanganyele nohlelo lwe-endocannabinoid ngokubophezela kuma-receptors e-CB1 kanye ne-CB2, atholakala ebuchosheni nasemzimbeni wonke. Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuqonda izindlela ezithile zokuthi i-CBT isebenzisana kanjani nohlelo lwe-endocannabinoid.
Ingabe i-CBT Isemthethweni?
Yebo, i-CBT isemthethweni ngaphansi koMthethosivivinywa Wepulazi ka-2018. Inqobo nje uma umkhiqizo ungaqukethe ngaphezu kuka-0.3% we-THC, kusemthethweni.
I-CBT ingase ibe nomthelela ohlelweni lwe-endocannabinoid. Uhlelo lwe-endocannabinoid luwuhlelo oluyinkimbinkimbi lokubonisa amaseli oludlala indima ekulawuleni izinqubo ezihlukahlukene zomzimba emzimbeni, njengobuhlungu, imizwa, nesifiso sokudla.
Ikusasa LamaCannabinoid Amancane
I-Cannabicitran (CBT) iyi-cannabinoid engavamile embonini ye-hemp ethola ukunakwa ngemiphumela yayo engase ibe khona engadaki efana ne-CBD ne-CBG kanye nezinzuzo zempilo ezingaba khona. Ngaphandle kokuntuleka kocwaningo, izifundo zakuqala ziphakamisa ukuthi i-CBT ingase ithuthukise imiphumela yamanye ama-cannabinoids, kube nomthelela ezinzuzweni zezempilo jikelele. Njengoba imboni ithuthuka, kuzojabulisa ukubona ukuthi i-CBT ingena kanjani esithombeni esikhulu se-hemp kanye nokusetshenziswa kwayo okungenzeka. Njengamanje, ukunaka okuningi kugxile ku-CBD ne-THC, kodwa njengoba ukuqonda kwethu ukusebenzisana kwalezi zinhlanganisela nomzimba kwanda, ukugxila kuzodlulela kwamanye ama-cannabinoids amancane angama-120 angaziwa kakhulu.
Extract Labs isonqenqemeni lokukhipha nokucubungula ama-cannabinoids amancane. Sijabule kakhulu ukubona ukuthi yiziphi izifundo ezizoveza amakhono esitshalo se-cannabis ukuze sibe nomthelela ezimpilweni zabantu futhi sikwazi ukuhlinzeka abathengi ngemikhiqizo ehlanzekile, ethembekile, nethengekayo ukuvumela wonke umuntu ukuthi abone ukuthi angabenzelani!
Imihlahlandlela eminingi ye-CBD | Iyini i-Delta 8 THC?
Yini i-Delta 8 THC?
Iyasebenza
Brogan, Andrew P., et al. "I-antibody-catalyzed oxidation ye-delta(9) -tetrahydrocannabinol." I-PubMed, 28 March 2007, https://pubmed.ncbi.nlm.nih.gov/17335216/. Ifinyelelwe ngomhla ka-25 Januwari 2023.
Elsohly, Mahmoud A., et al. "Ama-Cannabinoids ku-glaucoma II: Umphumela wama-cannabinoids ahlukene ekucindezelweni kwe-intraocular kanogwaja." U-Taylor noFrancis Online, 2009, https://www.tandfonline.com/doi/abs/10.3109/02713688409000797. Ifinyelelwe ngomhla ka-26 Januwari 2023.
U-Iwata, uNaoki, noSusumu Kitanaka. "Izinto ezintsha ezifana ne-cannabinoid ezifana ne-chromane ne-chromene ezivela ku-Rhododendron anthopogonoides." I-PubMed, 2011, https://pubmed.ncbi.nlm.nih.gov/22041081/. Ifinyelelwe ngomhla ka-25 Januwari 2023.
Kikiowo, Babtomiwa, et al. "I-Induced Fit Docking kanye ne-Automated QSAR Studies Zembula i-ER-a Inhibitory Activity of Cannabis Sativa in Breast Cancer." I-Eureka Select, 10 Agasti 2021, https://www.eurekaselect.com/article/113837. Ifinyelelwe ngomhla ka-26 Januwari 2023.
