I-CBDA (cannabidiolic acid) ingesinye sezinhlanganisela eziningi zamakhemikhali ongazithola ku-cannabis ne-hemp. Kungacatshangwa njengendlela eluhlaza ye-CBD, futhi ngokwayo ivela ku-CBGa (umama wawo wonke ama-cannabinoids). Nansi eminye imininingwane mayelana nezinqubo zamakhemikhali eziholela ekwakhiweni kwe-CBDA:

I-CBDA izalwa yi-CBGa ephuka ngaphambi kokuba ibe nesikhathi sokuguqulelwa ku-CBG. Indlela elula yokucabanga ngenqubo isitshalo se-hemp esikhiqiza i-CBGa ukuze sikhulise ukukhula kwaso njengoba sikhula. Ngemuva kwalokho, i-CBGa iguqukela ku-CBG ngokushisa nokukhanya kwelanga, noma isitshalo sidiliza i-CBGa phakathi nomjikelezo wokukhula ukuze siyiguqulele ngokwemvelo ku-CBDA, THCa, ne-CBCa. Ngayinye kulawa ma-cannabinoids amathathu angaguqulwa, ngezimo ezifanayo, abe yizinhlanganisela zawo ezingenayo i-asidi. I-THCa iba yi-THC, i-CBCa iba yi-CBC, futhi ekugcineni, i-CBDa iphenduka i-CBD iningi labathengi abayijwayele.

I-CBGa ithola elayo ithuba ekukhanyeni. I-Cannabigerolic acid (CBGa) ingenye yama-cannabinoids angaphezu kwe-100 akhona esitshalweni se-hemp. Abaningi babiza i-CBGa cannabinoids ngokuthi "umama wawo wonke ama-phytocannabinoids." Empeleni iyinhlanganisela eyisisekelo yesitshalo se-cannabis, enye yezakhiwo eziyisisekelo wonke ama-cannabinoids aqhamuka kuzo. I-CBGa ihlukana ibe amanye ama-molecule, okuhlanganisa i-cannabidiolic acid (CBDa), i-tetrahydrocannabinolic acid (THCa), kanye ne-cannabichromenic acid (CBCa). Ngaphezu kwalokho, i-CBGa yilokho okwaziwa njengesandulela esine-acidic ku-CBG, okusho ukuthi i-CBGa iguqulela ku-CBG ngaphansi kwezimo ezifanele - imvamisa ukushisa kanye/noma ukukhanya kwelanga.

I-CBDA yenzani kuwe? Ingabe i-CBDA inamandla kune-CBD? Lena eminye yemibuzo evame kakhulu esiyitholayo nge-CBDA.

Hhayi-ke, zombili azinangqondo, ngakho-ke ngeke zikunikeze umuzwa wokuba phezulu. Ucwaningo lwesayensi mayelana nemiphumela yama-cannabinoids luyaqhubeka, futhi akunakwenzeka okwamanje ukwenza izimangalo ezinkulu mayelana nemiphumela yawo. Kodwa-ke, ucwaningo luye lwabonisa ukuthi i-CBDA ingaba nezakhiwo ezisebenza kahle kune-CBD. Lezi izimpawu ezithembisayo, futhi zichaza ukuthi kungani abantu abaningi benentshisekelo ku-CBDA muva nje. Ngenxa yalokhu Extract Labs siyaziqhenya ngokuba ngomunye wamafutha e-CBDA angcono kakhulu emakethe.

Lutho neze. I-CBGa ingabizwa ngokuthi "umama wawo wonke ama-phytocannabinoids". I-CBG ingenye yama-cannabinoids amaningi angavela ku-CBGa njengoba eguqulela kwamanye ama-cannabinoids. 

I-CBGa kanye ne-CBDa sebeyisihloko socwaningo lwakamuva lokuthi ama-cannabinoids asebenzisana kanjani nohlelo lwe-endocannabinoid kanye nempilo yonke. Ucwaningo luthole ukuthi ama-cannabinoid acid amabili avame ukutholakala ku-hemp, i-cannabigerolic acid, i-CBGa, kanye ne-cannabidiolic acid, i-CBDa, angabopha kumaprotheni adala ukungaphatheki kahle. Ngokubophezela kumaprotheni, izinhlanganisela zinganikeza izindlela ezintsha zokusekela impilo yokuzivikela komzimba.

Kunomehluko ocashile phakathi kwamafutha e-CBDa angcono kakhulu nama-capsules e-CBDA. Njengoba kushiwo, amaphilisi e-CBDa adliwa ngokugwinya, kanti i-CBDA Amafutha ithathwa ngokungemthetho. Umthelela ophelele empilweni yakho uyafana kodwa uyahluka ngokuya ngobude. Ama-Capsules e-CBDa kulula ukuwahambisa, ngakho-ke abaningi bakhetha ama-softgel ngenxa nje yento elula. Ekugcineni, konke kuncike kulokho okuthandayo.

Ngoba amaphilisi e-CBDa namafutha e-CBKa amuncwa umzimba ngendlela ehlukile, isikhathi semiphumela ezwayo singahluka futhi. I-Sublingual CBDa Amafutha ngokuvamile azomunca ngokushesha egazini kunekhepsuli ye-CBDA egwinyiwe. Kodwa-ke, izinzuzo ze-CBD capsule zingazwakala isikhathi eside ngoba indlela umzimba nesibindi ocubungula ngayo uwoyela kumaphilisi.

Lutho neze. Izinhlobo ze-Acidic zama-cannabinoids azisebenzi ngokwengqondo kunozakwabo abangenayo i-asidi.

Inqobo nje uma zithathwe ku-hemp futhi ziqukethe okungaphansi kwezinga eligunyazwe nguhulumeni elingu-0.3% le-Delta 9 THC, zombili lezi zinhlanganisela zivikelwe uMthethosivivinywa Wepulazi ka-2018 ngakho-ke usemthethweni ngokomthetho.

Indlela osebenzisa ngayo noma onikeza ngayo imikhiqizo ye-cannabinoid ingathinta i-bioavailability yayo, okuwukuthi ingakanani into engena egazini ngesikhathi esithile.

Isibonelo, ukuhwamuka noma ukusetshenziswa kwezilimi ezingaphansi kuyindlela enhle yokungenisa ama-cannabinoids, njengoba enikeza i-bioavailability ephezulu, okusho ukuthi azongena egazini ngesivinini esisheshayo ngemiphumela ehlala isikhathi eside. Ngakolunye uhlangothi, ukusetshenziswa komlomo ngamaphilisi noma izinto ezidliwayo kuzongena egazini ngenani eliphansi elinemiphumela ehlala isikhathi eside. Izihloko zinikeza i-bioavailability ephansi kakhulu, njengoba imuncwa esikhumbeni.

Ukuqonda i-bioavailability kungakusiza ukuthi unqume ukuthi ungakanani umkhiqizo okufanele uwuthathe, futhi ngaluphi uhlobo, ukuze uqinisekise ukuthi umthamo ofanele uphela ohlelweni lwakho.